Effectiveness: 16% (4 in 25 or 1 in 6.25) compared to 1 in 20 for cold turkey
Two medications used to treat depression, bupropion and nortriptyline, help smokers who are trying to quit.
Trials of bupropion (Zyban) for smoking cessation indicate that it can approximately double the odds of quitting. The side effects of bupropion include insomnia, dry mouth and nausea. This medication can also cause seizures; at the dose used for smoking cessation the risk is estimated to be 1 in 1000. The tricyclic antidepressant nortriptyline also doubles quit rates. The side effects of this medication include dry mouth, constipation, nausea, and sedation, and it can be dangerous in overdose. The efficacy of bupropion and nortriptyline appears to be similar to that for nicotine replacement and not restricted to people with a history of depression or depressive symptoms during smoking abstinence. Selective serotonin reuptake inhibitor antidepressants (for example, fluoxetine) have not consistently been shown to help smoking cessation.
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